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March 4, 2025
By hiding inside macrophages (a type of white blood cell in blood and tissue which is the first line of defence against microbes) Enterobacter lies dormant and does not stimulate any inflammatory responses, allowing it to escape the action of the few antibiotics that remain available for treating the infection.
Enterobacter infections, including wound infections, urinary tract infections, gastroenteritis, meningitis, pneumonia and septicemia, are serious infections with a high mortality rate, even with appropriate treatment.
This breakthrough could help to develop new ways to treat infected patients and clear Enterobacter infections more efficiently, leading to less deaths.
The study has been published in the Journal of Infectious Diseases.
Source: https://www.qub.ac.uk/News/Allnews/featured-research/antibiotic-resistant-bacteria-hide-human-cells-without-alerting-immune-system.html