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Oct 31 , 2024
Neonatal sepsis, affecting infants in their first 28 days, occurs in 2-3 per 100 live births globally, particularly impacting preterm and low-birth-weight neonates. Mortality rates can reach 17.6%, especially in low/middle-income countries, with sepsis being a leading cause of neonatal death.
The non-specific clinical signs often delay diagnosis, making timely treatment critical. Current diagnostic methods, including blood cultures, are insufficient, emphasizing the urgent need for specific biomarkers to identify sepsis early and accurately. Further research is essential to develop predictive biomarkers for timely intervention.
Among this cohort, 33 neonates were hospitalized within 28 days due to clinical signs consistent with sepsis. Of these, 21 were diagnosed with sepsis based on either blood culture results or clinical diagnosis, while the remaining 12 had localized infections without systemic signs. Septic neonates were categorized into early-onset sepsis EOS and late-onset sepsis LOS