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Researchers identify new tools for anti-Acinetobacter drug development and AMR preparedness

September 10, 2024

University of Liverpool researchers have engineered a library of strains that can be used to develop new antibacterial compounds to help address antimicrobial resistance (AMR) in Acinetobacter baumannii bacteria.
 
Acinetobacter baumannii (or A. baumannii) is a bacterial species commonly found in environmental settings such as water and soil.
 
It is a known opportunistic pathogen that can cause serious infections, particularly in the bloodstream, urinary tract, lungs (resulting in pneumonia), or open wounds, especially in hospitalized or immunocompromised patients.
 
A. baumannii has been named as one of the top priority pathogens by the World Health Organization (WHO) and is the cause of most prevalent multi-drug resistant infections in healthcare settings.
 
A. baumannii persists in hostile environments by readily forming biofilms -- clusters of microorganisms that stick to non-biological surfaces -- and utilising multiple resistance mechanisms to overcome exposure to antimicrobial agents and other environmental toxins.
 

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