Biomaterials and Scaffolds for Sepsis Management:
Bioactive Coatings for Sepsis Prevention:
- Development and characterization of antimicrobial coatings for medical devices to prevent biofilm formation and sepsis risk.
- Incorporation of antimicrobial agents, such as silver nanoparticles or antimicrobial peptides, into biomaterial coatings.
- Evaluation of the efficacy and safety of bioactive coatings in reducing device-related infections and sepsis incidence.
Nanomaterials for Sepsis Diagnosis and Treatment:
- Nanoengineered platforms for rapid and sensitive detection of sepsis biomarkers in blood or bodily fluids.
- Nanoparticle-based drug delivery systems for targeted delivery of antimicrobial agents or immunomodulatory drugs to sites of infection.
- Investigation of the immunomodulatory effects of nanomaterials in sepsis therapy, including modulation of inflammatory responses and immune cell functions.
Biomaterial-based Hemocompatible Surfaces:
- Design and fabrication of blood-contacting biomaterials with improved hemocompatibility to prevent coagulation and thrombosis in sepsis.
- Surface modification strategies, such as grafting or coating with bioactive molecules, to enhance the biocompatibility and anti-thrombotic properties of biomaterials.
- In vitro and in vivo evaluation of hemocompatible biomaterials for use in extracorporeal devices, such as dialysis membranes or blood oxygenators, in sepsis management.
Biomaterials and Scaffolds for Wound Care:
Bioactive Dressings for Wound Healing:
- Development of advanced wound dressings incorporating bioactive components, such as growth factors, cytokines, or antimicrobial agents, to promote tissue regeneration and prevent infections.
- Fabrication techniques for producing bioactive dressings, including electrospinning, hydrogel encapsulation, and 3D bioprinting.
- Preclinical and clinical studies evaluating the efficacy and safety of bioactive dressings in promoting wound healing and preventing complications in various types of wounds.
Tissue Engineering Approaches for Chronic Wounds:
- Scaffold-based tissue engineering strategies for the regeneration of chronic wounds, including diabetic ulcers, venous ulcers, and pressure ulcers.
- Selection of biomaterials and scaffold fabrication techniques suitable for promoting cell infiltration, angiogenesis, and extracellular matrix deposition in chronic wound beds.
- Integration of bioactive factors, stem cells, or tissue-engineered constructs into wound dressings or implantable scaffolds for enhanced wound healing outcomes.
Smart Wound Dressings for Real-time Monitoring and Therapy:
- Design and development of smart wound dressings equipped with sensors or microfluidic channels for continuous monitoring of wound parameters, such as pH, temperature, or bacterial load.
- Incorporation of responsive materials or drug delivery systems into smart dressings for on-demand release of therapeutic agents in response to changes in wound conditions.
- Clinical translation and commercialization of smart wound dressings for personalized wound care management and telemedicine applications.
Biocompatible Scaffolds for Skin Regeneration:
- Engineering of biocompatible scaffolds for skin regeneration applications, including full-thickness wound repair, burn injury treatment, and aesthetic skin reconstruction.
- Optimization of scaffold properties, such as porosity, mechanical strength, and degradation kinetics, to mimic the native skin architecture and support cell infiltration and tissue integration.
- Preclinical and clinical evaluation of scaffold-based skin substitutes for promoting wound closure, reducing scar formation, and restoring skin function in patients with acute or chronic skin injuries.
