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July18, 2023
The MUSC team studied the content of EVs because they are produced in high numbers by white blood cells and platelets during sepsis. EVs carry proteins and RNA throughout the body that can modify the function of other cells that pick them up. When these modified cells penetrate through the walls of leaky blood vessels, organ damage can occur.
"Normal blood vessel walls could protect tissues; however, in a disease condition such as sepsis, larger molecules and cells can pass through this blood vessel wall, which can induce inflammation and will worsen the situation during sepsis," said Pengfei Li, Ph.D., lead author and staff scientist in the Department of Pathology and Laboratory Medicine.
"While further validation studies and larger cohorts of septic patients are necessary," said Li, "EV content could be a dynamic marker for sepsis."
Source:https://medicalxpress.com/news/2023-07-biomarker-sepsis-severity.html